For questions about BMS medicines during this time please call 1-800-721-8909.

Tools & resources

IDHIFA® Wallet Cards

  • This printable resource provides information about differentiation syndrome and other potential side effects of IDHIFA®
  • It also includes cards for you and your caregiver to cut out and keep in your wallets
  • If you visit the emergency room or a doctor who is not on your regular healthcare team, show this card so they will know you are being treated with IDHIFA®


This resource includes useful tools that you can use to prep for doctor’s visits. In it you’ll find:

  • Medication list
  • Appointment tracker
  • Important questions



During your journey with IDHIFA®, CPS® can provide you with a local Specialist who can:

  • Talk through any questions you may have
  • Provide assistance in understanding coverage for IDHIFA®
  • Outline information about financial assistance as you need it


Patient Brochure

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Caregiver Brochure

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Full Prescribing Information

Medication Guide

Not sure where to start? No problem.

Answer the following questions to receive a personalized list of IDHIFA® resources

Are you a patient or a caregiver?

Do you need more information from your doctor?

Do you need help paying for IDHIFA®?

Are you unsure about the common terms of AML?

Are you familiar with the potential side effect of IDHIFA®, differentiation syndrome?

IDHIFA® Wallet Cards

IDHIFA Wallet Cards

Caregiver Brochure

Patient Brochure




Use this page as a reference for any of the terms that may be difficult, or difficult to remember, during treatment. It’s also a useful guide for you to give to your caregiver, friends, and family, as they go through this journey with you.


An illness that will progress quickly if left untreated


Short for acute myeloid leukemia, a blood cancer of the bone marrow


Immature blood cells that are not usually found in the blood

Bone marrow

The soft interior of the bones where new blood cells are created


When there is a low number of healthy cells in the body


Of, or relating to, blood


Isocitrate dehydrogenase-2; the mutated enzyme that IDHIFA® targets through inhibition


An abnormal change within a cell


Help prevent bleeding caused by cuts and bruises

Red blood cells

Carry oxygen from the lungs to all cells in the body


Relapsed or refractory


The AML has not responded to any attempts at treatment


The signs and symptoms of AML have returned after a period of response to treatment


The signs and symptoms of AML decrease or go away entirely

White blood cells

Help the body fight infections. They are a crucial part of the body’s immune system

Are you a caregiver? Explore additional resources to help you care for your loved ones.


WHAT IS IDHIFA® (enasidenib)?

IDHIFA® is a prescription medicine used to treat people with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation whose disease has come back or has not improved after previous treatment(s). It is not known if IDHIFA is safe and effective in children.

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What is the most important information I should know about IDHIFA?

IDHIFA may cause serious side effects, including:

  • Differentiation Syndrome. Differentiation syndrome is a condition that affects your blood cells which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened within 1 day and up to 5 months after starting IDHIFA. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking IDHIFA:
    • fever
    • cough
    • shortness of breath
    • swelling of arms and legs
    • swelling around neck, groin, or underarm area
    • fast weight gain (greater than 10 pounds within a week)
    • bone pain

If you develop any of these symptoms of differentiation syndrome, your healthcare provider may start you on a medicine taken by mouth or given through a vein (intravenous) called corticosteroids and may monitor you in the hospital.


Before taking IDHIFA, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant, plan to become pregnant, or think you might be pregnant during treatment with IDHIFA. IDHIFA can cause harm to your unborn baby if taken during pregnancy
    • If you are able to become pregnant, your healthcare provider will do a pregnancy test before you start taking IDHIFA
    • Females who are able to become pregnant and who take IDHIFA should use effective birth control (contraception) during treatment with IDHIFA and for at least 2 months after your last dose of IDHIFA
    • Males who have female partners that are able to become pregnant should use effective birth control during treatment with IDHIFA and for at least 2 months after your last dose of IDHIFA
    • IDHIFA may affect how hormonal contraceptives work and may cause them to not work as well
    • Talk to your healthcare provider about birth control methods that may be right for you while taking IDHIFA
    • IDHIFA may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility
  • Are breastfeeding or plan to breastfeed. It is not known if IDHIFA passes into your breast milk. You should not breastfeed during your treatment with IDHIFA and for at least 2 months after your last dose of IDHIFA

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I take IDHIFA?

  • Take IDHIFA exactly as your healthcare provider tells you to
  • Take IDHIFA 1 time a day at the same time each day. IDHIFA can be taken with or without food
  • Swallow IDHIFA tablets whole with 8 ounces (one cup) of water. Do not chew or split the tablet
  • If you miss a dose of IDHIFA or vomit after taking a dose of IDHIFA, take the dose of IDHIFA as soon as possible on the same day. Then take your next dose the next day at your regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose
  • Your healthcare provider should do blood tests to check your blood counts before you start IDHIFA treatment and at a minimum of every 2 weeks for at least the first 3 months during treatment to check for side effects

What are the possible side effects of IDHIFA?

IDHIFA may cause serious side effects, including:

See "What is the most important information I should know about IDHIFA?"

The most common side effects of IDHIFA include:

  • nausea
  • vomiting
  • diarrhea
  • jaundice
  • decreased appetite

Tell your healthcare provider if you have any changes to the color of your skin or the whites of your eyes.

Your healthcare provider will monitor you for side effects during treatment and may tell you to stop taking IDHIFA if you develop certain side effects. These are not all the possible side effects of IDHIFA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.

General information about the safe and effective use of IDHIFA

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not take IDHIFA for conditions for which it was not prescribed. Do not give IDHIFA to other people, even if they have the same symptoms you have. It may harm them. You can ask your pharmacist or healthcare provider for information about IDHIFA that is written for health professionals.

Please see full Prescribing Information, including Boxed WARNING and Medication Guide.

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